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Faculty/Staff
Zhimin Feng, PhD

Zhimin Feng, PhD

Senior Instructor Department of Biological Sciences

zhimin.feng@cwru.edu 216.368.1996 (o)

Education

PhD, Cell Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
MS, Medical Biochemistry, School of Medicine, Southeast University, Nanjing, China
BS, Biochemistry, Nanjing University, Nanjing, China

Research Summary

Dr. Feng's research area is epithelial innate immunity. He is working on the regulation and function of human beta-defensins (hBDs), structure/function analysis of hBD-3 and CXCR4 interactions, as well as epithelial innate immune responses to microbial challenges.

Research Keywords

Innate immunity, Human beta defensins (hBDs), Epithelial biology, Microbial challenge

Zhimin Feng, George R. Dubyak, Michael M. Lederman, Aaron Weinberg. Cutting Edge: Human beta defensin 3─A novel antagonist of the HIV-1 co-receptor CXCR4. J. Immunol, 177: 782-786, 2006.

Z Feng, J Chandra, M Ghannoum, A Weinberg. Human beta-defensin activity against candida. J Dent Res, 84: 445-450, 2005.

Nicholas Funderburg, Michael M. Lederman, Zhimin Feng, Michael G. Drage, Julie Jadlowsky, Clifford V. Harding, Aaron Weinberg, and Scott F. Sieg. Human β defensin-3 activates professional antigen-presenting cells via Toll like Receptors 1 and 2. Proc. Nat. Acad. Sci, 104: 18631-18635, 2007.

ME Quinones-Mateu, MM Lederman, Z Feng, B Chakraborty, J Weber, HR Rangel, ML Marotta, M Mirza, B Jiang, P Kiser, K Medvik, SF Sieg and A Weinberg. Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication. AIDS, 17:F39 -F48, 2003

Z Feng, Aaron Weinberg. Role of bacteria in health and disease of periodontal tissues. Periodontology 2000, 40: 50-76, 2006.