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Mechanism of F. nucleatum in Intrauterine Infection

Sponsored by National Institutes of Health, National Institute of Dental and Craniofacial Research

Project Period: July 5, 2013 – June 30, 2017


Intrauterine infection is a major cause of pregnancy complications such as preterm birth and stillbirth. Fusobacterium nucleatum (Fn), a common oral bacterium, is one of the most prevalent species in intrauterine infection. Using a highly integrated and state-of-the-art approach, we will analyze the pathogenesis mechanisms of Fn in intrauterine infection to identify potential targets to treat and prevent intrauterine infection. Results from our study will have profound impact on our understanding of this devastating infectious disease and patient management. Moreover, it will shed novel light on how oral bacteria impact infections and inflammation at extra-oral sites.

Project Team

Yiping W. Han, PhDDepartment of Periodontics

Eric PearlmanDepartment of Ophthalmology and Visual Sciences

Dr. Yiping W. Han

Dr. Yiping W. Han, PhD
Principal Investigator

CWRU School of Dental Medicine     2124 Cornell Road     Cleveland, OH 44106-4905     216.368.3200