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Epigenetic Regulation of Viral Replication by Periodontal Bacteria


Sponsored by CWRU Center for AIDS Research Developmental Pilot Program


Project Period: May 1, 2013 - April 30, 2014


Abstract

This pilot project studies the mechanisms by which periodontal pathogens promote replication of HIV and herpesviruses in the oral cavity of HIV patients. More specifically, we investigate how short chain fatty acids from oral bacteria modulate cellular epigenetic regulatory machinery to induce viral gene expression and replication.

Project Team

Fengchun YeDepartment of Biological Sciences

Dr. Fengchun Ye

Dr. Fengchun Ye
Principal Investigator

CWRU School of Dental Medicine     2124 Cornell Road     Cleveland, OH 44106-4905     216.368.3200