HomeResearchResearch By Faculty/Staff Member › Dr. Yiping Han
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BS, Nanjing University
MS, University of Illinois at Urbana-Champaign
PhD, University of Illinois at Urbana-Champaign

Research Interests

Microbial pathogenesis, host-pathogen interactions, protein structure-function relationship, role of human microbiome in pregnancy complications, colorectal cancer, and inflammatory bowel disease, oral-systemic connections

Selected Publications

Rubinstein, M. R., Wang, Y., Liu, W., Hao, Y., Cai, G., and Han, Y. W. (2013) Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating the E-cadherin/-catenin signaling via its unique FadA adhesin. Cell Host & Microbe 14: 195-206.

Han, Y. W. and Wang, X. (2013) “Mobile microbiome: oral bacteria in extra-oral infections and inflammation.” J. Dent. Res. 92: 485-491.

Temoin, S., Wu, K. L., Wu, V., Shoham, M., and Han, Y. W. (2012) Signal peptide of FadA adhesin from Fusobacterium nucleatum plays a novel structural role by regulating the filament’s length and width. FEBS Lett. 586(1):1-6.

Fardini, Y., Wang, X., Temoin, S., Nithianantham, S., Lee, D., Shoham, M., and Han, Y. W. (2011) Fusobacterium nucleatum adhesin FadA binds vascular-endothelial cadherin and impairs endothelial integrity Mol. Microbiol. 82(6): 1468-1480.

Fardini, Y., Chung, P., Joshi, N., and Han, Y. W. (2010) "Transmission of diverse oral bacteria to murine placenta: evidence of oral microbiome as a source of intrauterine infection." Infect. Immun. 78 (4):1789-1796.

Han, Y. W., Fardini, Y., Chen, C., Iacampo, K. G., Peraino, V. A., Shamonki, J. M., and Redline, R. W. (2010) "Term stillbirth caused by oral Fusobacteriun nucleatum." Obstet. Gynecol. 115 (2):442-445.

Ikegami, A., Chung, P., and Han, Y. W. (2009) "Complementation of the fadA mutation in Fusobacterium nucleatum: the surface exposed adhesin promotes cellular invasion and placental colonization." Infect. Immun. 77(7):3075-3079.

Han, Y. W., Shen, T., Chung, P., Buhimschi, I. A., and Buhimschi, C. S. (2009) "Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth." J. Clin. Microbiol. 47(1):38-47.

Nithianantham, S., Xu, M., Ikegami, A., Yamada, M., Shoham, M., and Han, Y. W. (2009) "The crystal structure of the FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif: The leucine chain." J. Biol. Chem. 284(6):3865-3872.

Xu, M., Yamada, M., Li, M., and Chen, S. G., and Han, Y. W. (2007) "FadA from Fusobacterium nucleatum utilizes both secreted and non-secreted forms for functional oligomerization for attachment and invasion of host cells." J. Biol. Chem. 282:25000-25009.

Liu, H., Redline, R., and Han, Y. W. (2007) "Fusobacterium nucleatum induces fetal death in mice by stimulating TLR4-mediated inflammatory response." J. Immunol. 179:2501-2508.

Han, Y. W., Ikegami, A., Bissada, N., Herbst, M., Redline, R. W. and Ashmead, G. G. (2006) "Transmission of uncultivated Bergeyella sp. from the oral cavity to amniotic fluid in preterm birth." J. Clin. Microbiol. 44:1475-1483.

Han, Y. W., Ikegami, A., Rajanna, C, Kawsar, H. I., Zhou. Y., Li, M., Sojar, H., Genco, R. J., Kuramitsu, H. K., and Deng, C. X. (2005) "Identification and characterization of a novel adhesin unique to oral fusobacteria." J. Bacteriol. 187:5330-5340.

Han, Y. W., Redline, R. W., Li, M., Yin, L., Hill, G. B., and McCormick, T. S. (2004) "F. nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth." Infect. Immun. 72:2272-2279.

Professional Memberships

American Association for the Advancement of Science
International/American Association for Dental Research
American Association for Cancer Research
American Society for Biochemistry and Molecular Biology
American Society for Microbiology
International Federation of Placenta Associations

Dr. Yiping W. Han

Department of Periodontics
School of Dental Medicine

Department of Medicine (Oncology)
Department of Pathology
Department of Reproductive Biology
School of Medicine

Case Comprehensive Cancer Center

Email: yiping.han@case.edu
Phone: 216.368.1995

CWRU School of Dental Medicine     2124 Cornell Road     Cleveland, OH 44106-4905     216.368.3200