Education
M.S., University of Illinois at Urbana-Champaign
Ph.D., University of Illinois at Urbana-Champaign
Research Interests
Microbial pathogenesis, host-pathogen interactions, protein structure-function relationship, preterm birth, vaccine development
Selected Publications
Fardini, Y., Chung, P., Joshi, N., and Han, Y. W. (2010) "Transmission of diverse oral bacteria to murine placenta: evidence of oral microbiome as a source of intrauterine infection." Infect. Immun. 78 (4):1789-1796.
Han, Y. W., Fardini, Y., Chen, C., Iacampo, K. G., Peraino, V. A., Shamonki, J. M., and Redline, R. W. (2010) "Term stillbirth caused by oral Fusobacteriun nucleatum." Obstet. Gynecol. 115 (2):442-445.
Ikegami, A., Chung, P., and Han, Y. W. (2009) "Complementation of the fadA mutation in Fusobacterium nucleatum: the surface exposed adhesin promotes cellular invasion and placental colonization." Infect. Immun. 77(7):3075-3079.
Han, Y. W., Shen, T., Chung, P., Buhimschi, I. A., and Buhimschi, C. S. (2009) "Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth." J. Clin. Microbiol. 47(1):38-47.
Nithianantham, S., Xu, M., Ikegami, A., Yamada, M., Shoham, M., and Han, Y. W. (2009) "The crystal structure of the FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif: The leucine chain." J. Biol. Chem. 284(6):3865-3872.
Xu, M., Yamada, M., Li, M., and Chen, S. G., and Han, Y. W. (2007) "FadA from Fusobacterium nucleatum utilizes both secreted and non-secreted forms for functional oligomerization for attachment and invasion of host cells." J. Biol. Chem. 282:25000-25009.
Liu, H., Redline, R., and Han, Y. W. (2007) "Fusobacterium nucleatum induces fetal death in mice by stimulating TLR4-mediated inflammatory response." J. Immunol. 179:2501-2508.
Han, Y. W., Ikegami, A., Bissada, N., Herbst, M., Redline, R. W. and Ashmead, G. G. (2006) "Transmission of uncultivated Bergeyella sp. from the oral cavity to amniotic fluid in preterm birth." J. Clin. Microbiol. 44:1475-1483.
Han, Y. W., Ikegami, A., Rajanna, C, Kawsar, H. I., Zhou. Y., Li, M., Sojar, H., Genco, R. J., Kuramitsu, H. K., and Deng, C. X. (2005) "Identification and characterization of a novel adhesin unique to oral fusobacteria." J. Bacteriol. 187:5330-5340.
Han, Y. W., Redline, R. W., Li, M., Yin, L., Hill, G. B., and McCormick, T. S. (2004) "F. nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth." Infect. Immun. 72:2272-2279.
Professional Memberships
American Association for the Advancement of Science
International/American Association for Dental Research
American Society for Biochemistry and Molecular Biology
American Society for Microbiology
Professor
Department of Periodontics
School of Dental Medicine
Email: yiping.han@case.edu
Phone: 216.368.1995