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Faculty/Staff

Ge Jin, PhD

Ge Jin, PhD

Associate Professor, Department of Biological Sciences Member, Case Comprehensive Cancer Center

ge.jin@case.edu 216.368.3791 (o)

Education

PhD, Cell Biology, Department of Physiology and Biophysics, Case Western Reserve University
MSc, Shanghai Research Institute of Plant Physiology, Chinese Academy of Sciences, Shanghai, China

 

Research Summary

Dr. Ge Jin’s research focuses on identifying signals sent out by tumor cells that recruit and activate tumor-promoting immune cells, particularly tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), for cancer progression. His laboratory has discovered that human β-defensin-3 (hBD3), a secreted epithelial cell-derived protein, is overexpressed in and released by oral precancerous lesions and oral cancer cells at the invasive front, while production of hBD1 and hBD2 are reduced. Further studies in Dr. Jin’s laboratory has found that tumor cell-derived hBD3 is involved in TAM accumulation using the chemokine receptor CCR2 and stimulates macrophages to produce chemokines and cytokines, potentially forming a positive feedback loop driving tumor progression. In addition, his laboratory has identified that hBD3 production is driven by activation of growth factor receptors and inactivation of tumor suppressors, defined signaling networks previously identified to direct head and neck carcinogenesis. Dr. Jin’s laboratory recently finds that high-risk human papillomaviruses (HPVs), which are involved the progression of a subset of head and neck cancer, induce production of hBD3 through the tumor suppressor. Most recently, Dr. Jin is working on an NIH sponsored project to investigate the immune response and potential immunotherapeutic targets of head and neck cancer. He has been collaborating with researchers in the Department and with members of the Case Comprehensive Cancer Center to develop biomarkers of head and neck cancer and other solid tumors.

 

Kawsar HI, Weinberg A, Hirsch SA, Venizelos A, Howell S, Jiang B, Jin G, Overexpression of human β-defensin-3 in oral dysplasia: Potential role in macrophage trafficking. Oral Oncol. 45 (7):696-702 (2009)

Jin G, Kawsar HI, Hirsch SA, Zeng C, Jia X, Feng Z, Ghosh SK, Zheng QY, Zhou A, McIntyre TM, Weinberg A. An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis. PLoS One. 5 (6): e10993 (2010).

Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, and Howe PH. TGFβ-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat. Cell Biol. 12 (3): 286-293 (2010).

Jin G. Using biomarker to detect oral cancer holds potential for saving lives when the cancer is most curable. Biomark Med. 4(6): 835-838 (2010).

Kawsar HI, Ghosh SK, Hirsch SA, Koon HB, Weinberg A, and Jin G. Expression of human β-defensin-2 in intratumoral vascular endothelium and in endothelial cells induced by transforming growth factor-β. Peptides. 31 (2): 195-201 (2010).

Head Neck Cancer, beta-Defensins, and Immune Responses – R01
Role: Principal Investigator
Sponsor: NIH-NIDCR
Project Period: 07/2015 – 06/2020

Innate Immunity and Oral Carcinogenesis – R56
Role: Principal Investigator
Sponsor: NIH-NIDCR
Project Period: 7/2011 – 6/2012

Human β-defensins as Novel Biomarkers for Precancerous Lesions of Colorectal Cancer – Pilot Grant
Role: Principal Investigator
Sponsor: Case Compressive Cancer Center
Project Period: 4/2011 – 3/2012

Biomarkers of Human Papillomavirus-associated Head and Neck cancer
Role: Principal Investigator
Sponsor: STERIS Corporation
Funding Period: 8/2011 – 7/2012

Role of Human β-defensin-3 in the Progression of Tumors – Pilot Grant
Role: Principal Investigator
Sponsor: American Cancer Society
Project Period: 9/2009 – 8/2010

Functional Genomic Screen of the Transforming Growth Factor-β Signaling Molecules – SDG
Role: Principal Investigator
Sponsor: American Heart Association
Funding Period: 7/2005 – 6/2009

 

Body as Host (HEWB 128)

Foundation of Life Sciences (HEWB 121) Problem-Based Learning Component

Heart & Lungs in Health & Disease (HWDP 131) Problem-Based Learning Component