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Pushpa Pandiyan, PhD

Pushpa Pandiyan, PhD

Assistant Professor Department of Biological Sciences 216.368.2939 (o)


PhD, Immunology, German Arthritis Research Center, Humboldt University, Berlin Germany
MSc, Life Sciences (Microbiology), Bharathidasan University, India

Research Summary

Optimal immune responses are required to fight infections. However, if the immune responses are not regulated appropriately, they can cause inflammatory disorders. I am studying the mechanisms by which unwanted immune responses are regulated. I am focusing on how regulatory T cells (Tregs) and cytokine networks control inflammatory cells in different disease settings.

Research Keywords

Tregs, Th17 cells, candidiasis, HIV, candida infection, inflammation, IBD

Pandiyan, P., Gartner, D., Soezeri, O., Radbruch, A., Schulze-Osthoff, K., and Brunner-Weinzierl, M. C.: CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring P13’kinase function. J. Exp. Med. 199: 831-842, 2004.

Pandiyan, P., Hegel, J.K., Krueger, M., Quandt, D., and Brunner-Weinzierl, M.C.: High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4). J. Immunology. 178: 2132-2140, 2007.

Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., and Lenardo, M.: CD4+CD25+ Foxp3+ Tregs cause cytokine deprivation apoptosis of effector CD4 T cells. Nature Immunology. 8: 1353-1362, 2007. (RESEARCH HIGHLIGHTS in Science, NEWS & VIEWS in Nature Immunology)

Pandiyan, P., Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL and Lenardo MJ. CD4+ CD25+ Foxp3+ regulatory T cells up-regulate Th17 cytokines in vitro and promote host resistance in mouse Candida albicans Th17 infection model. Immunity. 34: March 2011. (highlighted in RESEARCH HIGHLIGHTS - in Immunity and Nature Review Immunology., Vol 11, 2011)

Pandiyan, P., Yang, X, Saravanamuthu S, Ishihara S, Zheng, L, O’Shea J and Lenardo MJ. The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. In press, Journal of Immunology, 2012

NIAID, NIH- 2010 Performance Award for Special Achievement, 2010, 2011, and 2012
Post-doctoral Fellow Award, International Cytokine Society (ICS)(2008)
FDA/NIH Cytokine Interest Group (CIG) Award: Paper of the Year 2007, awarded to the best publication in cytokine research
AAI Travel Award, 2008
American Association of Immunologists (AAI) - Invitrogen Trainee Achievement Award, 2008
National Academy of Sciences Postdoctoral Fellowship, USA 2006-2009
NIH Travel Grant, Keystone Conference, USA 2003
Travel Grant, Humboldt University, Germany 2003
Humboldt University Grant - PhD fellowship, Germany 2001-2003