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Fengchun Ye, PhD

Fengchun Ye, PhD

Assistant Professor Department of Biological Sciences 216.368.0230 (o)


PhD, Molecular Microbiology, University of Bordeaux II, Bordeaux, France
MS, Molecular Microbiology, University of Bordeaux II, Bordeaux, France
BS, Horticulture, Huazhong Agricultural University, Wuhan, China

Research Summary

My research area is pathogenesis of oncogenic viruses such as Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). I am currently working on how periodontal bacteria enhance viral replication in the oral cavity to promote oral cancer in HIV/AIDS patients. I also work on how KSHV infection promotes angiogenesis, inflammation, and tumor growth.

Research Keywords

Kaposi sarcoma (KS), KSHV, HIV, periodontal bacteria, angiogenesis, inflammation, oral cancer

Fengchun Ye, Lattif AA, Xie J, Weinberg A, and Gao S. Nutlin-3 Induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells. Cell Cycle. 2012, 11(7): 1393-9.

Greene W, Zhang W, Witt C, Fengchun Ye, and Gao S-J. The ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpes virus in endothelia cells. PLoS Pathogens, 2012, 8(5): e1002703.

Jones T*, Fengchun Ye1,3*, Bedolla, R *, Huang YF, Meng J, Qian LW, Pan H, Moody R, Wagner B, Arar M, Zhou F, and Gao S-J. Direct Cellular Transformation of Primary Mesenchymal Precursor Cells by Kaposi's Sarcoma-Associated Herpes virus. J. Clin. Investigation. 2012, 122 (3): 1076-81.

Fengchun Ye, Zhou FC, Bedolla R. G, Junes T, Lei XF, Kang T, Guadalupe M, and Gao S-J. Reactive oxgen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathogens, 2011, 7 (5): e1002054

Lei XF, Bai ZQ, Fengchun Ye, Xie JP, Kim CG, Huang YF, and Gao S-J. Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA. Nature Cell Biol, 2010, 12: 193-199.

American Society of Microbiology
Center for AIDS Research (CFAR), CWRU, Cleveland, Ohio