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Epigenetic Regulation of Viral Infection and Replication by Periodontal Bacteria

Sponsored by National Institutes of Health, National Institute of Dental and Craniofacial Research
Project Period: September 23, 2013 - August 31, 2015


The purpose of the present study is to investigate the regulation of the host cell epigenetic machinery by metabolic products from periodontal bacteria and the impact on enhancing viral replication and infection in the oral cavity of HIV patients. The results should provide a scientific basis for developing novel strategies to prevent and treat recurrent HIV and herpesviral infections in HIV/AIDS patients simultaneously.

Project Team

Fengchun Ye – Department of Biological Sciences

Jonathan Karn - Department of Molecular Biology and Microbiology

John Tilton - Center for Proteomics and Bioinformatives

Aaron Weinberg - Department of Biological Sciences

Dr. Fengchun Ye
Dr. Fengchun Ye
Principal Investigator